Family

Multivesicular body subunit 12 (IPR018798)

Short name: MVB12A/B

Overlapping homologous superfamilies

None.

Family relationships

Description

MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle [PMID: 20654576, PMID: 24284069]. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor [PMID: 16895919].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000813 ESCRT I complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam