Transcription factor, enhancer of yellow 2 (IPR018783)

Short name: TF_ENY2

Overlapping homologous superfamilies

Family relationships



Enhancer of yellow 2 (EnY2) is a small transcription factor which is conserved from protozoa to humans [PMID: 11438676]. In insects it is known as enhancer of yellow 2 transcription factor, but in other organisms is known as transcription and mRNA export factor SUS1 or ENY2. It is involved in mRNA export coupled transcription activation by association with both the TREX-2 complex and the transcription regulatory histone acetylation complex SAGA [PMID: 14718168, PMID: 21746879, PMID: 18923079, PMID: 18034162]. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B [PMID: 18206972, PMID: 16855026]. The TREX-2 complex participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery [PMID: 22307388].

GO terms

Biological Process

GO:0006406 mRNA export from nucleus
GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

GO:0003713 transcription coactivator activity

Cellular Component

GO:0000124 SAGA complex
GO:0005643 nuclear pore

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.