Domain

Brl1/Brr6 domain (IPR018767)

Short name: Brl1/Brr6_dom

Domain relationships

None.

Description

In Saccharomyces cerevisiae, Brr6 and Brl1 are interacting proteins that localise to the nuclear envelope and regulate lipid homeostasis [PMID: 26432634]. Mutation studies have implicated the proteins in nuclear pore complex biogenesis and mRNA nuclear export [PMID: 11483521], although it may be that these observed effects are due to defects in maintaining the biophysical properties of the nuclear envelope [PMID: 26432634].

This entry represents a highly conserved domain found in the C terminus of Brl1 and in Brr6. It is likely that this domain plays an important role in their interaction. Mutation studies have shown the domain to be essential for Brl1 function [PMID: 15882446].

Interestingly, many fungi, including Saccharomyces cerevisiae, contain both Brr6 and Brl1 genes. However, S. pombe,Pneumocystis carinii, and other fungi distantly related to S. cerevisiae have a unique gene that is more closely related to Brl1 than to Brr6 [PMID: 26432634]. The S. pombe homologue has been shown to be involved in SPB biogenesis [PMID: 22042620].

GO terms

Biological Process

GO:0055088 lipid homeostasis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031965 nuclear membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART