Domain

Brl1/Brr6 domain (IPR018767)

Short name: Brl1/Brr6_dom

Domain relationships

None.

Description

This entry represents a highly conserved domain found in the C terminus of fungal protein Brl1, which is a nuclear envelope protein required for nuclear transport [PMID: 15882446]. The domain is also found in the related fungal protein Brr6, which is an essential nuclear envelope integral membrane protein that is required for mRNA nuclear export [PMID: 11483521].

Brr6 and Brl1 interact to form a complex, and it is likely that this domain plays an important role in their binding. Mutation studies have shown the domain to be essential for Brl1 function [PMID: 15882446].

GO terms

Biological Process

GO:0006406 mRNA export from nucleus
GO:0006998 nuclear envelope organization
GO:0006611 protein export from nucleus

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031965 nuclear membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART