Dpy-19/Dpy-19-like (IPR018732)

Short name: Dpy-19/Dpy-19-like

Overlapping homologous superfamilies


Family relationships


This entry represents the Dpy-19 protein from Caenorhabditis elegans and its homologues in other Metazoa, including mammals. In C. elegans, Dpy-19 is required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis. These neuroblasts are born in the same A/P position, but polarise and migrate left/right asymmetrically, where QL migrates toward the posterior and QR migrates toward the anterior. After their migrations, QL (but not QR) switches on the Hox gene mab-5. Dpy-19 is required along with Unc-40 to express Mab-5 correctly in the Q cell descendants [PMID: 11023868].

A mammalian dpy-19 homologue was found to be expressed in GABAergic neurons [PMID: 15944814]. The mammalian homologue of Mab-5 is the Gsh2 homeobox transcription factor, which plays a crucial role in the development of GABAergic neurons.

Dpy-19 has been shown recently to be a C-mannosyltransferase that mediates C-mannosylation of tryptophan residues [PMID: 23562325].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.