Autophagy-related protein 13, N-terminal (IPR018731)

Short name: Atg13_N

Overlapping homologous superfamilies

Domain relationships



This entry represents the N-terminal domain of autophagy-related protein 13 (Atg13) from yeasts, animals and plants. They function in autophagy.

Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. Atg13 recruits Atg1 to the site of autophagosome formation and enhancing Atg1 kinase activity. Atg13 may have additional functions that are independent of a direct interaction or permanent colocalization with Atg1 [PMID: 24879146].

In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101 [PMID: 24879146]. Through its regulation of ULK1 activity, Atg13 plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation [PMID: 19225151].

GO terms

Biological Process

GO:0006914 autophagy

Molecular Function

No terms assigned in this category.

Cellular Component

GO:1990316 Atg1/ULK1 kinase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.