Autophagy-related protein 13 (IPR018731)
Short name: Atg13
Overlapping homologous superfamilies
- HORMA domain superfamily (IPR036570)
This entry represents autophagy-related protein 13 (Atg13) from yeasts, animals and plants. They function in autophagy.
Fission yeast autophagy initiation is controlled by the Atg1 kinase complex, which is composed of the Ser/Thr kinase Atg1, the adaptor protein Atg13, and the ternary complex of Atg17-Atg31-Atg29. Atg13 recruits Atg1 to the site of autophagosome formation and enhancing Atg1 kinase activity. Atg13 may have additional functions that are independent of a direct interaction or permanent colocalization with Atg1 [PMID: 24879146].
In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101 [PMID: 24879146]. Through its regulation of ULK1 activity, Atg13 plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation [PMID: 19225151].
- PF10033 (ATG13)