Family

RZZ complex, subunit Zwilch (IPR018630)

Short name: Zwilch

Family relationships

None.

Description

The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores [PMID: 12686595, PMID: 15886105, PMID: 17576797].

Zwilch is a component of the RZZ complex, which is composed of Rod, Zw10 and Zwilch.

GO terms

Biological Process

GO:0007093 mitotic cell cycle checkpoint

Molecular Function

No terms assigned in this category.

Cellular Component

GO:1990423 RZZ complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam