Translocation protein Sec66 (IPR018624)

Short name: Sec66

Overlapping homologous superfamilies


Family relationships



Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. Furthermore, Sec66 is also required for growth at elevated temperatures [PMID: 8257795, PMID: 8257794, PMID: 2000150, PMID: 7758110].

GO terms

Biological Process

GO:0031204 posttranslational protein targeting to membrane, translocation

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0031207 Sec62/Sec63 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.