Structure-specific endonuclease subunit Slx4 (IPR018574)

Short name: Structure-sp_endonuc_su_Slx4

Overlapping homologous superfamilies


Family relationships


The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 is a regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination [PMID: 19595721, PMID: 19596236]. The SLX1-SLX4 complex has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs) [PMID: 12832395, PMID: 18471978].

Defects in SLX4 are the cause of Fanconi anemia complementation group P (FANCP), which is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia [PMID: 21240277, PMID: 21240275].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0006260 DNA replication

Molecular Function

GO:0017108 5'-flap endonuclease activity

Cellular Component

GO:0033557 Slx1-Slx4 complex
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.