Centromere protein X (IPR018552)

Short name: CENP-X

Overlapping homologous superfamilies


Family relationships



Centromere protein X (CENP-X) is a component of several different complexes, including the multisubunit FA complex, the heterotetrameric CENP-T-W-S-X complex and the APITD1/CENPS complex.

The Fanconi anemia (FA) core complex is involved in DNA damage repair and genome maintenance. The FA complex is composed of CENPS, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and CENPX. Interacts with CENPS, FANCM and FAAP24 [PMID: 20347428, PMID: 20347429]. Inner kinetochore subunit mhf2 is the dsDNA-binding component of the FANCM-MHF complex, important for gene conversion at blocked replication forks [PMID: 20347428] and non-crossover recombination during mitosis and meiosis [PMID: 22723423].

The CENP-T-W-S-X complex binds, supercoils DNA and plays an important role in kinetochore assembly [PMID: 22304917].

The APITD1/CENPS complex is composed of at least of CENP-S and CENP-X and is essential for the stable assembly of the outer kinetchore [PMID: 19620631].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0051382 kinetochore assembly

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.