Domain

Btz domain (IPR018545)

Short name: Btz_dom

Domain relationships

None.

Description

This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein, also known as MLN51) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [PMID: 16923391, PMID: 14973490].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
SMART