Aspartyl-phosphate phosphatase Spo0E-like (IPR018540)

Short name: Spo0E-like

Overlapping homologous superfamilies

Family relationships



Spo0E is an aspartyl-phosphate phosphatase which specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation [PMID: 18045868]. The structure of Spo0E has revealed an anti-parallel alpha-helical structure [PMID: 17001075].

Spore formation is an extreme response to starvation and can also be a component of disease transmission. Sporulation is controlled by an expanded two-component system where starvation signals result in sensor kinase activation and phosphorylation of the master sporulation response regulator Spo0A. Phosphatases such as Spo0E dephosphorylate Spo0A thereby inhibiting sporulation [PMID: 15057450].

GO terms

Biological Process

GO:0043937 regulation of sporulation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.