SUN domain-containing protein 1 (IPR018539)

Short name: SUN1

Overlapping homologous superfamilies


Family relationships



SUN domain-containing protein 1 is a nuclear inner membrane protein and a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [PMID: 22945352].

SUN1 contains a conserved Sad1p/UNC-84 (SUN)-domain at its C terminus that can associate with Klarsicht/ANC-1/Syne homology (KASH)-domain proteins [PMID: 17158909]. The structure of the LINC complex has been solved [PMID: 22632968]. I mammals, SUN1 is widely expressed and can bind to all four Nesprins (KASH-domain containing proteins) [PMID: 22632968].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005639 integral component of nuclear inner membrane
GO:0034993 meiotic nuclear membrane microtubule tethering complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.