Family

SUN domain-containing protein 1 (IPR018539)

Short name: SUN1

Family relationships

None.

Description

SUN domain-containing protein 1 is a nuclear inner membrane protein and a component of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [PMID: 22945352].

SUN1 contains a conserved Sad1p/UNC-84 (SUN)-domain at its C terminus that can associate with Klarsicht/ANC-1/Syne homology (KASH)-domain proteins [PMID: 17158909]. The structure of the LINC complex has been solved [PMID: 22632968]. I mammals, SUN1 is widely expressed and can bind to all four Nesprins (KASH-domain containing proteins) [PMID: 22632968].

This entry also includes the C. elegans SUN domain containing proteins, SUN1 and UNC-84. In C. elegans, SUN1 is involved in centrosome attachment to the nucleus and is required for zyg-12 localisation to the nuclear envelope [PMID: 14697201]. UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration [PMID: 25057012].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0034993 LINC complex
GO:0005639 integral component of nuclear inner membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER