Domain

DDT domain (IPR018501)

Short name: DDT_dom

Domain relationships

None.

Description

The DDT has been named after the better characterised DNA-binding homeobox- containing proteins and the Different Transcription and chromatin remodelling factors in which it is found. It is a domain of about 60 amino acids which is exclusively associated with nuclear domains like AT-Hook, PHD finger, methyl-CpG-binding domain, bromodomain and DNA-binding homeodomain.

The DDT domain is characterised by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. A DNA-binding function for the DDT domain has been proposed [PMID: 11246006].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
PROSITE profiles
SMART