Conserved Site

Succinate dehydrogenase, cytochrome b subunit, conserved site (IPR018495)

Short name: Succ_DH_cyt_bsu_CS


Succinate dehydrogenase (SDH) is a membrane-bound complex of two main components: a membrane-extrinsic component composed of an FAD-binding flavoprotein and an iron-sulphur protein, and a hydrophobic component composed of a cytochrome b and a membrane anchor protein. The cytochrome b component is a mono-haem transmembrane protein [PMID: 1447196, PMID: 8152421, PMID: 7616569] belonging to a family that includes:

  • Cytochrome b-556 from bacterial SDH (gene sdhC).
  • Cytochrome b560 from the mammalian mitochondrial SDH complex, which is encoded in the mitochondrial genome of some algae and in the plant Marchantia polymorpha.
  • Cytochrome b from yeast mitochondrial SDH complex (gene SDH3 or CYB3).
  • Protein cyt-1 from Caenorhabditis elegans.

These cytochromes are proteins of about 130 residues that comprise three transmembrane regions. There are two conserved histidines which may be involved in binding the haem group.

GO terms

Biological Process

GO:0006099 tricarboxylic acid cycle

Molecular Function

GO:0009055 electron transfer activity
GO:0000104 succinate dehydrogenase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns