Monopolin complex subunit Lrs4/Mde4 (IPR018479)

Short name: Lrs4/Mde4

Overlapping homologous superfamilies


Family relationships



Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae (Baker's yeast), that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [PMID: 11163190]. The orthologous complex in Schizosaccharomyces pombe (Fission yeast) is not required for meiosis I chromosome segregation, but is proposed to play a similar physiological role in clamping microtubule binding sites [PMID: 17627824]. In S. cerevisiae this subunit is called Lrs4, and in S. pombe it is known as Mde4 [PMID: 12689592].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.