Family

Bicaudal-D protein, microtubule-associated (IPR018477)

Short name: Bicaudal-D_microtubule-assoc

Family relationships

None.

Description

BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER) [PMID: 19018277]. Glycogen synthase kinase-3beta (GSK-3beta) is required for the binding of BICD to dynein but not to dynactin, acting to maintain the anchoring of microtubules to the centromere [PMID: 17139249]. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells [PMID: 17139249].

GO terms

Biological Process

GO:0006810 transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005794 Golgi apparatus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam