Growth arrest/ DNA-damage-inducible protein-interacting protein 1 (IPR018472)

Short name: Damage-induce-interacting_prot

Overlapping homologous superfamilies


Family relationships



Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity [PMID: 12716909]. They may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.

GO terms

Biological Process

GO:0007049 cell cycle

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.