Dual oxidase maturation factor (IPR018469)

Short name: Dual_oxidase_maturation_fac

Overlapping homologous superfamilies


Family relationships



DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N terminus (type III) and two N-glycosylation sites [PMID: 16651268]. It is conserved from nematodes to humans.

GO terms

Biological Process

GO:0015031 protein transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.