SFR1/Mei5 family (IPR018468)

Short name: SFR1/Mei5

Overlapping homologous superfamilies


Family relationships



This entry includes Mei5 from budding yeasts and SFR1 from animals and fission yeasts. Although the fission yeast Swi5-Sfr1 complex is critical for homologous recombination repair, the budding yeast counterpart Sae3-Mei5 complex is meiosis-specific, interacts with Dmc1, and promotes assembly of Dmc1 on meiotic chromosomes [PMID: 21252223].

SFR is a component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination [PMID: 21252223].

Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologues, Rad51 and Dmc1 [PMID: 15620352]. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.