Centromere protein Scm3/HJURP (IPR018465)
Short name: Scm3/HJURP
Overlapping homologous superfamilies
- Histone-fold (IPR009072)
This entry includes human holliday junction recognition protein (HJURP) and its homologue, Scm3 from budding yeasts.
HJURP is a histone chaperone that plays a central role in the incorporation and maintenance of histone H3-like variant CENP-A at centromeres [PMID: 19410544].
Scm3 is a non-histone component of centromeric chromatin that binds to CenH3-H4 histones, which are required for kinetochore assembly. Scm3 is required for Cse4 (CENP- homologue) localisation and is required for its centromeric association [PMID: 17574026, PMID: 17569568]. The histone H3 variant Cse4 replaces conventional histone H3 in centromeric chromatin and helps direct the assembly of the kinetochore. In addition, Scm3 has is required for G2/M progression [PMID: 17548816] and is required to maintain kinetochore function throughout the cell cycle. Scm3 contains a nuclear export signal (NES). The N-terminal region of Scm3 is well conserved and functions as the CenH3-interacting domain, while the C-terminal region is variable in size and sometimes consists of DNA binding motifs [PMID: 17704645].
- PF10384 (Scm3)