Centromere protein O (IPR018464)

Short name: CENP-O

Overlapping homologous superfamilies


Family relationships



This entry represents centromere protein O (CENP-O) and its homologues in yeasts, Mcm21 and Mal2.

In humans, centromere protein O (CENP-O) is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation [PMID: 16622419]. CENP-O mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. CENP-O modulates the kinetochore-bound levels of NDC80 complex [PMID: 18007590]. It may be involved in incorporation of newly synthesized CENP-A into centromeres via its interaction with the CENPA-NAC complex [PMID: 16622420].

In Saccharomyces cerevisiae, Mcm21 is a component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p), which links kinetochore subunits with subunits bound to microtubules during kinetochore assembly [PMID: 14633972, PMID: 22561346].

In Schizosaccharomyces pombe, Mal2 is a component of the Sim4 complex, which is required for loading the DASH complex onto the kinetochore via interaction with Dad1 [PMID: 12242294]. It plays a role in the maintenance of core chromatin structure and kinetochore function [PMID: 16079914].

GO terms

Biological Process

GO:0034508 centromere complex assembly

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000776 kinetochore

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.