Conserved Site

PTR2 family proton/oligopeptide symporter, conserved site (IPR018456)

Short name: PTR2_symporter_CS

Description

The transport of peptides into cells is a well-documented biological phenomenon which is accomplished by specific, energy-dependent transporters found in a number of organisms as diverse as bacteria and humans. The PTR family of proteins is distinct from the ABC-type peptide transporters and was uncovered by sequence analyses of a number of recently discovered peptide transport proteins [PMID: 7476181]. These proteins that seem to be mainly involved in the intake of small peptides with the concomitant uptake of a proton [PMID: 7817396].

These integral membrane proteins are predicted to comprise twelve transmembrane regions.

This entry describes two conserved sites. The first conserved site is found within a region that includes the end of the second transmembrane region, a cytoplasmic loop as well as the third transmembrane region. The second conserved site corresponds to the core of the fifth transmembrane region.

GO terms

Biological Process

GO:0006857 oligopeptide transport

Molecular Function

GO:0005215 transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns