Conserved Site

Corticotropin-releasing factor conserved site (IPR018446)

Short name: Corticotropin-releasing_fac_CS


Corticotropin-releasing factor (CRF) (corticoliberin) [PMID: 2200028] is a hormone from the hypothalamus that regulates the release of corticotropin (ACTH) from the pituitary gland. CRF is evolutionary related to a number of other active peptides which are listed below.

  • Urocortin (Ucn) [PMID: 7477349], a brain mammalian peptide with corticotropin-releasing factor activity.
  • Urotensin 1 from the urophysis of fish. Like CRF and Ucn, it acts in ACTH secretion.
  • Sauvagine from frog skin, a peptide with a potent hypotensive action that elicits a diuretic effect.
  • Diuretic hormone (DH) (or diuretic peptide (DP) from a variety of insects. DH is involved in the regulation of fluid secretion [PMID: 7991460].

All these hormones are peptides of about 40 amino acid residues which are C-terminally amidated and processed from a larger precursor protein. This signature is a pattern of conserved residues, running from position 4 to 19 in these peptides.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns