Family

Lysosomal-associated transmembrane protein 5 (IPR018397)

Short name: Lysosomal-assoc_TM_prot5

Overlapping homologous superfamilies

None.

Family relationships

Description

The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes.

This entry represents LAPTM5, which is a lysosomal protein expressed in cells of lymphoid and myeloid origin. LAPTM5 trafficking from the Golgi to the lysosome requires its association with the ubiquitin ligase Nedd4 and the clathrin adaptor GGA3 [PMID: 17116753]. LAPTM5 negatively regulates T and B cell receptor signaling by directly interacting with these receptors and mediating their down-regulation [PMID: 20519653, PMID: 18619870]. It is also a positive regulator of NF-kB and MAPK signaling allowing efficient proinflammatory cytokine production in response to macrophage activation [PMID: 22733818].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005764 lysosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER