Lysosomal-associated transmembrane protein, 4A/5 (IPR018396)

Short name: LAPTM_4A/5

Overlapping homologous superfamilies


Family relationships


The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes.

This entry represents LAPTM4 alpha (LAPTM4A) and LAPTM45. LAPTM4A regulates the intracellular compartmentalisation of amphipathic solutes and possibly the sensitivity of cells toward anthracyclines, antibiotics, ionophores, nucleobases and organic cations [PMID: 11980562, PMID: 10519401]. LAPTM5 may have functional role during embryogenesis and in adult hematopoietic cells [PMID: 19787053].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.