LysM domain (IPR018392)

Short name: LysM_dom

Overlapping homologous superfamilies

Domain relationships


The LysM (lysin motif) domain is a small globular domain, approximately 40 amino acids long. It is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls [PMID: 1352512], but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis [PMID: 15120137]. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes [PMID: 10369758].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles