Conserved Site

CCAAT-binding factor, conserved site (IPR018362)

Short name: CCAAT-binding_factor_CS


The CCAAT-binding factor (CBFB/NF-YA) is a mammalian transcription factor that binds to a CCAAT motif in the promoters of a wide variety of genes, including type I collagen and albumin [PMID: 2266139]. The factor is a heteromeric complex of A and B subunits, both of which are required for DNA-binding [PMID: 1549471]. The subunits can interact in the absence of DNA-binding, conserved regions in each being important in mediating this interaction.

The B subunit contains a region of similarity with the yeast protein HAP2 [PMID: 2000400]. For the B subunit it has been suggested that the N-terminal portion of the conserved region is involved in subunit interaction and the C-terminal region involved in DNA-binding [PMID: 1569083].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

GO:0016602 CCAAT-binding factor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns