Rad4/PNGase transglutaminase-like fold (IPR018325)

Short name: Rad4/PNGase_transGLS-fold

Overlapping homologous superfamilies

Domain relationships



RAD4/Xp-C proteins contain an ancient transglutaminase fold that is also found in peptide-N-glycanases (PNGases), which remove glycans from glycoproteins during their degradation. The PNGases retain the catalytic triad that is typical of this fold and are predicted to have a reaction mechanism similar to that involved in transglutamination. In contrast, the RAD4/Xp-C proteins are predicted to be inactive and are likely to only possess the interaction function in DNA repair [PMID: 11487565].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.