Pathways & interactions
Solute-binding protein family 3, conserved site (IPR018313)
Short name: SBP_3_CS
Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [PMID: 8003968, PMID: 18310026].
On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [PMID: 8336670] into eight families or clusters, which generally correlate with the nature of the solute bound. This entry represents a conserved site found in the extracellular solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea.
Familiy 3 members include:
- Histidine-binding protein (gene hisJ) of Escherichia coli and related bacteria. An homologous lipoprotein exists in Neisseria gonorrhoeae.
- Lysine/arginine/ornithine-binding proteins (LAO) (gene argT) of Escherichia coli and related bacteria are involved in the same transport system than hisJ. Both solute-binding proteins interact with a common membrane-bound receptor hisP of the binding protein dependent transport system HisQMP.
- Glutamine-binding proteins (gene glnH) of Escherichia coli and Bacillus stearothermophilus.
- Glutamate-binding protein (gene gluB) of Corynebacterium glutamicum.
- Arginine-binding proteins artI and artJ of Escherichia coli.
- Nopaline-binding protein (gene nocT) from Agrobacterium tumefaciens.
- Octopine-binding protein (gene occT) from Agrobacterium tumefaciens.
- Major cell-binding factor (CBF1) (gene: peb1A) from Campylobacter jejuni.
- Bacteroides nodosus protein aabA.
- Cyclohexadienyl/arogenate dehydratase of Pseudomonas aeruginosa, a periplasmic enzyme which forms an alternative pathway for phenylalanine biosynthesis.
- Escherichia coli protein fliY.
- Vibrio harveyi protein patH.
- Escherichia coli hypothetical protein ydhW.
- Bacillus subtilis hypothetical protein yckB.
- Bacillus subtilis hypothetical protein yckK.
- PS01039 (SBP_BACTERIAL_3)