Conserved Site

Chromosomal replication control, initiator DnaA, conserved site (IPR018312)

Short name: Chromosome_initiator_DnaA_CS

Description

The bacterial dnaA protein [PMID: 8110826, PMID: 1779750, PMID: 2558436] plays an important role in initiating and regulating chromosomal replication. DnaA is an ATP- and DNA-binding protein. It binds specifically to 9 bp nucleotide repeats known as dnaA boxes which are found in the chromosome origin of replication (oriC).

DnaA is a protein of about 50 kDa that contains two conserved regions: the first is located in the N-terminal half and corresponds to the ATP-binding domain, the second is located in the C-terminal half and could be involved in DNA-binding. The protein may also bind the RNA polymerase beta subunit, the dnaB and dnaZ proteins, and the groE gene products (chaperonins) [PMID: 2172087].

The signature pattern in this entry is located in the most conserved part of the putative DNA-binding domain.

GO terms

Biological Process

GO:0006270 DNA replication initiation
GO:0006275 regulation of DNA replication

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns