Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain (IPR018302)

Short name: CenpF/LEK1_Rb-prot-bd

Overlapping homologous superfamilies


Domain relationships



This entry represents the Rb protein-binding domain from the centromere protein Cenp-F. Cenp-F is a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, that is involved in chromosome segregation during mitosis and is essential for the full functioning of the mitotic checkpoint pathway [PMID: 7542657, PMID: 14555653]. Cenp-F interacts with retinoblastoma protein (RB), CENP-E and BUBR1. This domain is at the very C terminus of the C-terminal coiled-coil region, and binds to the Rb family of tumour suppressors [PMID: 17498689].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.