Conserved Site

FLAP/GST2/LTC4S, conserved site (IPR018295)

Short name: FLAP/GST2/LTC4S_CS

Description

These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature for these proteins a conserved region between the first and second transmembrane domains has been used.

This entry contains the following mammalian proteins, which are evolutionary related [PMID: 8703034]:

  • Leukotriene C4 synthase (EC:4.4.1.20) (gene LTC4S), an enzyme that catalyzes the production of LTC4 from LTA4.
  • Microsomal glutathione S-transferase II (EC:2.5.1.18) (GST-II) (gene GST2), an enzyme that can also produces LTC4 fron LTA4.
  • 5-lipoxygenase activating protein (gene FLAP), a protein that seems to be required for the activation of 5-lipoxygenase.

GO terms

Biological Process

GO:0006691 leukotriene metabolic process

Molecular Function

GO:0008047 enzyme activator activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns