Conserved Site

43kDa postsynaptic, conserved site (IPR018293)

Short name: Postsynaptic_CS


The 43kDa postsynaptic protein is a peripheral membrane protein thought to be involved in the anchoring or stabilisation of the nicotinic acetylcholine receptor at synaptic sites [PMID: 2737281]. It may link the receptor to the postsynaptic cytoskeleton through direct association with actin or spectrin. The 43 kDa protein is highly conserved across species. Two highly conserved regions, one encompassing the N terminus and the other near the C terminus, may be important for interaction of the protein with other components of the postsynaptic membrane. This entry represents the N-terminal sequence of the mature protein (after removal of the initiator methionine); the resulting N-terminal glycine is thought to be myristoylated.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0033130 acetylcholine receptor binding

Cellular Component

GO:0045202 synapse

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns