Domain

DET1- and DDB1-associated protein 1, N-terminal (IPR018276)

Short name: DDA1_N

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

This entry represents the N-terminal domain of DDA1 (DET1- and DDB1-associated protein 1) ubiquitin ligase, which binds strongly with Det1 (De-etiolated 1) and DDB1 (Damaged DNA binding protein 1 associated 1). Together DDA1, DDB1 and Det1 form the DDD core complex, which recruits a specific UBE2E enzyme to form specific DDD-E2 complexes [PMID: 17452440]. Component of the DDD-E2 complexes which may provide a platform for interaction with cul4a and WD repeat proteins. These proteins may be involved in ubiquitination and subsequent proteasomal degradation of target proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam