PTM

Neuromodulin, palmitoylation/phosphorylation site (IPR018243)

Short name: Neuromodulin_palmitoyl/P_site

Description

Neuromodulin is a component of the motile growth cones. It is membrane protein whose expression is widely correlated with successful axon elongation [PMID: 3272162]. It is a crucial component of an effective regeneration response in the nervous system [PMID: 2641999]. Although its function is uncertain, the N-terminal region is well conserved and contains both a calmodulin binding domain, and sites for acylation, membrane attachment and protein kinase C phosphorylation. Structure predictions suggest that the C- terminus may exist as an extended, negatively-charged rod with some similarity to the side arms of neurofilaments, indicating that the biological role of neuromodulin may depend on its ability to form a dynamic membrane-cytoplasm-calmodulin complex [PMID: 2641999].

Two functionally important regions have been characterised: the first conserved region (NEUROMODULIN_1) in the N-terminal extremity contains two cysteine residues which are palmitoylated and are responsible for the attachment of the protein to the membrane; The second conserved region (NEUROMODULIN_2) about forty residues downstream contains a serine residue which can be phosphorylated by protein kinase C [PMID: 2140056] and which is adjacent to the calmodulin-binding domain.

GO terms

Biological Process

GO:0040008 regulation of growth

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns