Conserved Site

Clathrin adaptor, mu subunit, conserved site (IPR018240)

Short name: Clathrin_mu_CS

Description

This entry represents the mu subunit of various clathrin adaptors (AP1, AP2 and AP3) [PMID: 11583591]. The mu subunit regulates the coupling of clathrin lattices with particular membrane proteins by self-phosphorylation via a mechanism that is still unclear [PMID: 1761056]. The mu subunit possesses a highly conserved N-terminal domain of around 230 amino acids, which may be the region of interaction with other AP proteins; a linker region of between 10 and 42 amino acids; and a less well-conserved C-terminal domain of around 190 amino acids, which may be the site of specific interaction with the protein being transported in the vesicle [PMID: 1761056].

GO terms

Biological Process

GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030131 clathrin adaptor complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns