Conserved Site

Glycoside hydrolase, family 37, conserved site (IPR018232)

Short name: Glyco_hydro_37_CS


O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 37 GH37 comprises enzymes with only one known activity; trehalase (EC:

Trehalase is the enzyme responsible for the degradation of the disaccharide alpha,alpha-trehalose yielding two glucose subunits [PMID: 8444853]. It is an enzyme found in a wide variety of organisms and whose sequence has been highly conserved throughout evolution.

GO terms

Biological Process

GO:0005991 trehalose metabolic process

Molecular Function

GO:0004555 alpha,alpha-trehalase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns