Active Site

Glycoside hydrolase family 9, His active site (IPR018221)

Short name: Glyco_hydro_9_His_AS


The microbial degradation of cellulose and xylans requires several types of enzymes such as endoglucanases, cellobiohydrolases (exoglucanases), or xylanases [PMID: 2252383, PMID: 1886523]. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family E [PMID: 2806912] or as the glycosyl hydrolases family 9 [PMID: 1747104].

Two of the most conserved regions in these enzymes are centred on conserved residues which have been shown [PMID: 2037583, PMID: 1637316], in the endoglucanase D from Cellulomonas thermocellum, to be important for the catalytic activity. The first region contains an active site histidine and the second region contains two catalytically important residues: an aspartate and a glutamate.

This entry represents the firs conserved region containing a histidine.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns