Active Site

Ribonuclease T2, His active site 1 (IPR018188)

Short name: RNase_T2_His_AS_1


The fungal ribonucleases T2 from Aspergillus oryzae, M from Aspergillus saitoi and Rh from Rhizopeus niveus are structurally and functionally related 30 Kd glycoproteins [PMID: 2229029] that cleave the 3'-5' internucleotide linkage of RNA via a nucleotide 2',3'-cyclic phosphate intermediates (EC:

Two histidines residues have been shown [PMID: 2298207, PMID: 1633875] to be involved in the catalytic mechanism of RNase T2 and Rh. These residues and the region around them are highly conserved.

This entry represents the conserved region containing the first His active site.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding
GO:0033897 ribonuclease T2 activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns