Conserved Site

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site (IPR018168)

Short name: Ubi_Hdrlase_CS

Description

This entry represents FAD-dependent hydroxylases (monooxygenases) which are all believed to act in the aerobic ubiquinone biosynthesis pathway [PMID: 11583838]. A separate set of hydroxylases, as yet undiscovered, are believed to be active under anaerobic conditions [PMID: 365223]. In Escherichia coli, three enzyme activities have been described: UbiB (which acts first at position 6, see IPR010232), UbiH (which acts at position 4, [PMID: 11153266]) and UbiF (which acts at position 5, [PMID: 10802164]). UbiH and UbiF are similar to one another and form the basis of this subfamily. Interestingly, E. coli contains another hydroxylase gene, called visC, that is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (which has also been named visB) [PMID: 1339425]. Several other species appear to have three homologs in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, [PMID: 12721307]) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.

This entry represents the conserved site of the ubiquinone biosynthesis hydroxylase enzyme.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns