Conserved Site

Transcription elongation factor, GreA/GreB, conserved site (IPR018151)

Short name: TF_GreA/GreB_CS


Bacterial proteins GreA and GreB [PMID: 8431948, PMID: 7854424], are related proteins of about 160 amino-acid residues, and are necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. Arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked DNA/RNA/ polymerase ternary complexes. Cleavage of the nascent transcript by cleavage factors, such as GreA or GreB, allows the resumption of elongation from the new 3'-terminus. GreA induces cleavage 2 or 3 nucleotides behind the terminus while GreB releases longer sequences up to 9 nucleotides in length.

GO terms

Biological Process

GO:0032784 regulation of DNA-templated transcription, elongation

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns