Conserved Site

Glyoxalase I, conserved site (IPR018146)

Short name: Glyoxalase_1_CS

Description

Glyoxalase I (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway in the following reaction: glutathione + methylglyoxal = (R)-S-lactoylglutathione S-lactoylglutathione is then converted by glyoxalase II to lactic acid [PMID: 7684374]. Glyoxalase I is a ubiquitous enzyme which binds one mole of zinc per subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved. In bacteria and mammals the enzyme is a protein of about 130 to 180 residues while in fungi it is about twice as long. In these organisms the enzyme is built out of the tandem repeat of a homologous domain.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004462 lactoylglutathione lyase activity
GO:0046872 metal ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns