Active Site

Glycoside hydrolase, family 1, active site (IPR018120)

Short name: Glyco_hydro_1_AS


Glycoside hydrolase family 1 GH1 comprises enzymes with a number of known activities; beta-glucosidase (EC:; beta-galactosidase (EC:; 6-phospho-beta-galactosidase (EC:; 6-phospho-beta-glucosidase (EC:; lactase-phlorizin hydrolase (EC:, (EC:; beta-mannosidase (EC:; myrosinase (EC:

One of the conserved regions in these enzymes is centred on a conserved glutamic acid residue which has been shown in the beta-glucosidase from Agrobacterium, to be directly involved in glycosidic bond cleavage by acting as a nucleophile. We have used this region as a signature pattern. As a second signature pattern we selected a conserved region, found in the N-terminal extremity of these enzymes, this region also contains a glutamic acid residue. This pattern will pick up the last two domains of LPH; the first two domains, which are removed from the LPH precursor by proteolytic processing, have lost the active site glutamate and may therefore be inactive [PMID: 1732212].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns