Conserved Site

Mandelate racemase/muconate lactonizing enzyme, conserved site (IPR018110)

Short name: Mandel_Rmase/mucon_lact_enz_CS


Mandelate racemase EC: (MR) and muconate lactonizing enzyme EC: (MLE) are two bacterial enzymes involved in aromatic acid catabolism. They catalyze mechanistically distinct reactions yet they are related at the level of their primary, quaternary (homooctamer) and tertiary structures [PMID: 2215699, PMID: 8256284]. A number of other proteins also seem to be evolutionary related to these two enzymes. These include, various plasmid-encoded chloromuconate cycloisomerases EC:, Escherichia coli protein rspA [PMID: 7545940], E. coli bifunctional DGOA protein, E. coli hypothetical proteins ycjG, yfaW and yidU and a hypothetical protein from Streptomyces ambofaciens [PMID: 8277241].

GO terms

Biological Process

GO:0009063 cellular amino acid catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns