Conserved Site

CAP, conserved site, N-terminal (IPR018106)

Short name: CAP_CS_N


This entry represents the N-terminal conserved site of the CAP protein. Structurally, CAP is a protein of 474 to 551 residues, which consist of two domains separated by a proline-rich hinge. In budding and fission yeasts the CAP protein is a bifunctional protein whose N-terminal domain binds to adenylyl cyclase, thereby enabling that enzyme to be activated by upstream regulatory signals, such as Ras. The N terminus also catalyses cofilin-mediated severing of actin filaments [PMID: 23135996]. The C-terminal domain plays a role in recycling cofilin-bound, ADP-actin monomers [PMID: 23135996].

CAP is conserved in higher eukaryotic organisms. Although the role in Ras signalling does not extend beyond yeasts, the actin regulation function is conserved in all eukaryotes [PMID: 23737525].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns