Conserved Site

Translationally controlled tumour protein, conserved site (IPR018103)

Short name: Translation_control_tumour_CS

Description

The translationally controlled tumor proteins (TCTPs, such as p21, p23 and histamine releasing factor (HRF)) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in a variety of cellular functions, including microtubule stabilization, cell cycle, apoptosis, and cytokine release. TCTP is ubiquitously expressed in all eukaryotic organisms from protozoa such as Plasmodium sp. to plants and mammals [PMID: 11473261, PMID: 19262129, PMID: 18274553, PMID: 23085438].

This entry represents two conserved sites in these proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns