Conserved Site

Hok/gef cell toxic protein, conserved site (IPR018084)

Short name: Hok/gef_toxin_CS


The hok/gef family of Gram-negative bacterial proteins are toxic to cells when over-expressed, killing the cells from within by interfering with a vital function in the cell membrane [PMID: 3070354]. Some family members (flm) increase the stability of unstable RNA [PMID: 3070354], some (pnd) induce the degradation of stable RNA at higher than optimum growth temperatures [PMID: 2465777], amongst others, affect the release of cellular magnesium by membrane alterations [PMID: 2465777]. The proteins are short (50-70 residues), consisting of an N-terminal hydrophobic (possibly membrane spanning) domain, and a C-terminal periplasmic region, which contains the toxic domain. The C-terminal region contains a conserved cysteine residue that mediates homo-dimerisation in the gef protein, although dimerisation is not necessary for the toxic effect [PMID: 1943700].

This entry represents a conserved region found within these proteins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns