Conserved Site

Sterol reductase, conserved site (IPR018083)

Short name: Sterol_reductase_CS

Description

The following enzymes belong to a conserved family of sterol reductases which act by reducing double bonds [PMID: 8125337, PMID: 9878250]:

  • Fungal delta(14)-sterol reductase (EC:1.3.1.70) (C-14 sterol reductase) (gene ERG24 in budding yeast), an enzyme of ergosterol biosynthesis.
  • Mammalian (TM7SF2) and plant delta(14)-sterol reductases.
  • Fungal delta(24(24(1)))-sterol reductase (EC:1.3.1.71) (C-24(28) sterol reductase) (gene ERG4 in budding yeast), an enzyme of ergosterol biosynthesis.
  • Mammalian 7-dehydrocholesterol reductase (EC:1.3.1.21) which produces cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7- DHC).
  • Lamin B receptor, which is thought to anchor the lamina to the inner nuclear membrane.

All these proteins are highly hydrophobic and seem to contain seven or eight transmembrane regions.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns