Conserved Site

Band 7/stomatin-like, conserved site (IPR018080)

Short name: Band_7/stomatin-like_CS


Stomatin is also known as erythrocyte membrane protein band 7.2b. It is a 31 kDa membrane protein [PMID: 9147127], and was named after the rare human disease: haemolytic anaemia hereditary stomatocytosis. The protein contains a single hydrophobic domain, close to the N terminus, and is phosphorylated [PMID: 9147127].

Stomatin is believed to be involved in regulating monovalent cation transport through lipid membranes. Absence of the protein in hereditary stomatocytosis is believed to be the reason for the leakage of Na+ and K+ ions into and from erythrocytes [PMID: 9147127].

A second function of stomatin is to act as a cytoskeletal anchor. One possible example of this is its interaction with some anti-malarial drugs. Current opinion speculates that such drugs bind to high density lipoproteins in serum. The lipoproteins are delivered to erythrocytes, where it is believed they Interact with stomatin as a means of transfer to the intracellular parasite, via a pathway used for the uptake of exogenous phospholipid [PMID: 9088993].

Stomatin-like proteins have been identified in various organisms, including Caenorhabditis elegans and Mus musculus.

This domain covers a small conserved region located about 110 residues after the transmembrane domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns