Conserved Site

Protein phosphatase 2A, regulatory subunit PR55, conserved site (IPR018067)

Short name: PP2A_PR55_CS

Description

Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase implicated in many cellular processes, including the regulation of metabolic enzymes and proteins involved in signal transduction [PMID: 1849734, PMID: 1370560]. PP2A is a trimer composed of a 36 kDa catalytic subunit, a 65 kDa regulatory subunit (subunit A) and a variable third subunit (subunit B) [PMID: 1849734, PMID: 1370560].

One form of the third subunit is a 55 kDa protein (PR55), which exists in Drosophila melanogaster and yeast, and has up to three forms in mammals [PMID: 1849734, PMID: 1370560]. PR55 may act as a substrate recognition unit, or may help to target the enzyme to the correct subcellular location [PMID: 1849734].

This entry represents conserved regions found in the N-terminal region and the centre of these proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns
PROSITE patterns